90% of consumers

PHOTO : Paul Housberg/Glass Project, Inc.

As we age, the expression, or activity, of our genes changes and this affects our ability to feel young. ageLOC® R2 is a powerful product combination that works by targeting YGCs related to cellular purification and cellular energy production toward a more youthful time. Taken in the evening, ageLOC® R2 Night optimizes each cell’s natural purification process, helping you start each day feeling refreshed and renewed. Taken in the morning, ageLOC® R2 Day optimizes cellular energy production to help you recharge and take control of a new day. Renew and recharge with ageLOC® R2 .

In conclusion, the ageLOC Vitality formula enhances endurance exercise ability in aged mice by increasing the exercise time to exhaustion with improvement of mitochondria bio-energy metabolism and attenuation of the exercise-induced increase in blood lactic acid.     https://www.fasebj.org/doi/abs/10.1096/fasebj.25.1_supplement.1114.9

Oxidative injury and inflammation are intimately involved in the aging process and the development of age‐related diseases. To date, most nutritional antiaging strategies have focused solely on the delivery of exogenous antioxidants to combat the negative effects of aging. A promising new strategy is to identify nutrients and phytochemicals that can directly target intrinsic cytoprotective mechanisms, including modulation of the expression of (1) genes involved in the detoxification of xenobiotics, (2) genes involved in the synthesis and regulation of intrinsic antioxidants and antioxidant enzymes, (3) genes involved in the regulation of inflammation, and (4) vitagenes. The purpose of this review is to provide an overview of the age‐related changes in gene expression related to oxidative stress, detoxification, and inflammatory processes, and to discuss natural compounds with the potential to oppose age‐related changes in gene expression related to these processes, which therefore may be suitable for use in human antiaging research.

1. By middle age, expression of Nrf2 was
downregulated in liver, but not in skeletal muscle,
suggesting that either Nrf2 is not downregulated in
skeletal muscle with age or that middle-age is too
early to detect changes in Nrf2.
2. The phytonutrient blend effectively opposed the
downregulation of Nrf2 in liver observed in middleage
3. In addition to restoring the expression of the master
regulator Nrf2, the supplement opposed agerelated
changes in the expression of several Nrf2-
regulated genes in liver and muscle, suggesting
that it may combat some negative effects of aging.
4. Although many individual genes related to cellular
detoxification were changed with age, none of the
GO Pathways related to detoxification had changed
significantly by middle-age indicating that these
pathways decline at a later age.
5. Conversely, some pathways related to DNA
integrity were changed by middle-age.
6. The supplement opposed most age related
changes related to DNA repair. In addition, the
supplement upregulated some DNA repair
pathways that had not changed by middle age
suggesting that by intervening at a younger age,
the supplement may have stimulated protective
mechanisms before they had the chance to
7. These effects, elicited by a mid-life nutritional
intervention, will likely have positive implications for
healthy human aging or ‘youthspan’ and warrant
further investigation.
Mastaloudis A1; Barger JL2; Prolla TA2,3; Weindruch R2, 3; Wood SM1 A unique blend of natural compounds opposes age-related changes in gene expression related to dysregulation of cellular detoxification and antioxidant protection 1Nu Skin Enterprises Center for Anti-Aging Research, Provo, Utah, USA; 2LifeGen Technologies, Madison, Wisconsin, USA; 3University of Wisconsin, Madison, Wisconsin, USA
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