90% of consumers

PHOTO : Paul Housberg/Glass Project, Inc.

As we age, the expression, or activity, of our genes changes and this affects our ability to feel young. ageLOC® R2 is a powerful product combination that works by targeting YGCs related to cellular purification and cellular energy production toward a more youthful time. Taken in the evening, ageLOC® R2 Night optimizes each cell’s natural purification process, helping you start each day feeling refreshed and renewed. Taken in the morning, ageLOC® R2 Day optimizes cellular energy production to help you recharge and take control of a new day. Renew and recharge with ageLOC® R2 .

In conclusion, the ageLOC Vitality formula enhances endurance exercise ability in aged mice by increasing the exercise time to exhaustion with improvement of mitochondria bio-energy metabolism and attenuation of the exercise-induced increase in blood lactic acid.     https://www.fasebj.org/doi/abs/10.1096/fasebj.25.1_supplement.1114.9

Oxidative injury and inflammation are intimately involved in the aging process and the development of age‐related diseases. To date, most nutritional antiaging strategies have focused solely on the delivery of exogenous antioxidants to combat the negative effects of aging. A promising new strategy is to identify nutrients and phytochemicals that can directly target intrinsic cytoprotective mechanisms, including modulation of the expression of (1) genes involved in the detoxification of xenobiotics, (2) genes involved in the synthesis and regulation of intrinsic antioxidants and antioxidant enzymes, (3) genes involved in the regulation of inflammation, and (4) vitagenes. The purpose of this review is to provide an overview of the age‐related changes in gene expression related to oxidative stress, detoxification, and inflammatory processes, and to discuss natural compounds with the potential to oppose age‐related changes in gene expression related to these processes, which therefore may be suitable for use in human antiaging research.

Angela Mastaloudis Steven M. Wood

1. By middle age, expression of Nrf2 was

downregulated in liver, but not in skeletal muscle,

suggesting that either Nrf2 is not downregulated in

skeletal muscle with age or that middle-age is too

early to detect changes in Nrf2.

2. The phytonutrient blend effectively opposed the

downregulation of Nrf2 in liver observed in middleage

controls.

3. In addition to restoring the expression of the master

regulator Nrf2, the supplement opposed agerelated

changes in the expression of several Nrf2-

regulated genes in liver and muscle, suggesting

that it may combat some negative effects of aging.

4. Although many individual genes related to cellular

detoxification were changed with age, none of the

GO Pathways related to detoxification had changed

significantly by middle-age indicating that these

pathways decline at a later age.

5. Conversely, some pathways related to DNA

integrity were changed by middle-age.

6. The supplement opposed most age related

changes related to DNA repair. In addition, the

supplement upregulated some DNA repair

pathways that had not changed by middle age

suggesting that by intervening at a younger age,

the supplement may have stimulated protective

mechanisms before they had the chance to

decline.

7. These effects, elicited by a mid-life nutritional

intervention, will likely have positive implications for

healthy human aging or ‘youthspan’ and warrant

further investigation.

Mastaloudis A1; Barger JL2; Prolla TA2,3; Weindruch R2, 3; Wood SM1 A unique blend of natural compounds opposes age-related changes in gene expression related to dysregulation of cellular detoxification and antioxidant protection 1Nu Skin Enterprises Center for Anti-Aging Research, Provo, Utah, USA; 2LifeGen Technologies, Madison, Wisconsin, USA; 3University of Wisconsin, Madison, Wisconsin, USA