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The science of LifeGen Technologies utilizes DNA microarrays to identify changes in gene expression that are associated with the aging process and how these changes are opposed by caloric restriction (CR). The same process is being used by LifeGen scientists to screen for compounds that have the ability to mimic the transcriptional activity of CR.
This research will permit LifeGen to partner with companies to develop pharmaceutical and nutraceutical compounds to retard aging. LifeGen has also constructed an extensive, proprietary gene expression database on aging, which provides vital information to life sciences companies. Drs. Weindruch’s and Prolla’s knowledge, experience, and network of contacts in the gerontology, genetics and biotechnology industries provide LifeGen with the resources to be a leader in the field of aging genomics.
List of Publications
Identification of Tissue-Specific Transcriptional Markers of Caloric Restriction in The Mouse and Their Use to Evaluate Caloric Restriction Mimetics
Aging Cell. 2017; Aug;16(4):750-760
A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3
PLoS One. 2015; 10(4):e0120738
Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse
Genes & Nutrition 2012; 7(2):155-165
Caloric restriction delays disease onset and mortality in rhesus monkeys
Science. 2009; 325(5937):201-4
Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants
Aging Cell. 2009; 8(4):484-95
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart
Experimental Gerontology 2008; 43(9):859-66
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
PLoS One. 2008 Jun 4;3(6):e2264
alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice
Journal of Nutrition 2008; 138(6):1010-8
Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.
Journal of Nutrition 2006; 136(2):343-52
Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts
Science. 1999; 285(5432):1390-3
Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice
Journal of Nutrition 2001; 131(3):918S-923S
Gene-expression profile of the ageing brain in mice
Nature Genetics 2000; 25(3):294-7
Gene expression profile of aging and its retardation by caloric restriction
Science. 1999; 285(5432):1390-3
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