Cordyceps sinensis has traditionally been used in China as a strategy to combat aging. We have reported the e ects of Cordyceps sinensis Cs-4 (Cs-4) a mycelia fermentation product of C. sinensis, in glucose-lipid-energy metabolisms, anti-fatigue, and endurance enhancement. In this study, we examined the e ect of Cs-4 on lifespan extension and antioxidant status in mice. For the lifespanextension study, 250 mice 12 months of age (both sexes) received either vehicle or Cs-4 (0.5, 1.0 or 1.5g/kg diet). Caloric intake was adjusted to match the levels for controls twice per week. Compared to controls, the Cs-4 dosage group’ s 75% survival time was extended 94-108 days, 50% survival time extended 10-66 days, 25% survival time extended 29–44 days, and 12.5% survival time extended 7–50 days (86 weeks so far; treatment continues). The Kaplan-Meier Survivor analysis revealed the extended lifespan and the reduced risks of death by Cs-4. The antioxidant activity was tested in mice (6 months old) that received 60 days of vehicle or Cs-4 (0.5, 1.0 or 1.5 g/kg diet) and a single dose of 11Gy 60Co gamma-radiation on day 60. Compared to controls, Cs-4 prevented the depletion of plasma total thiol-groups, GSH and GSH-peroxidase, liver CAT, SOD, and GSH-reductase (p<0.05) caused by radiation exposure. Cs-4 also prevented the radiation-induced increases in liver protein carbonyls and 8-OHdG (p<0.05) observed in the control group. In conclusion, Cs-4 supplementation signifi cantly improves the body’s antioxidant capacity and extends the lifespan in mice, supporting the traditional anti-aging uses of Cs-4 in humans.

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