Alcohol and liver

Proprietary blend of D-glucarate, milk thistle extract (with silymarin), N-acetyl-L-cysteine and vitamin C promote the neutralization and elimination of toxic metabolites and foreign chemicals in the liver*
Powerful blend of liver-protective antioxidants protects and maintains healthy liver cells and stimulates the normal growth of healthy liver cells*
Offers a special blend of ingredients that help promote the stimulation of normal bile flow the livers second line of defense against toxic chemicals*
Contains D-glucarate, a patented compound that has been scientifically validated to protect the body from harmful toxic metabolites. D-glucarate is a compound produced endogenously in humans and is also found in grapefruit, apples, brussels sprouts, and other plant sources.*
Provides vitamin C and N-acetyl-L-cysteine as dietary precursors to glutathione, the livers most important antioxidant for both phase I and II detoxification pathways*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Free Register Wholesale price Sponzor ID Alexander Vasko SK5500064

Scientific Studies Detox Formula
Anonymous. Artichoke extract: Improves digestion, liver function, and cholesterol levels.
Natural Medicine Journal 1998;1:22-4.
Anonymous. The milk thistles. Lawrence Review of Natural Products 1985;6(January):1-3.
Berg-Candolfi M, Candolfi E, Benet LZ. Suppression of intestinal and hepatic
cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and
N(G)-monomethyl-L-arginine on the hepatic suppression. Xenobiotica 1996;26:381-94.
Bindoli A, Cavallini L, Siliprandi N. Inhibitory action of silymarin of lipid peroxide
formation in rat liver mitochondria and microsomes. Biochemical Pharmacology
Blumenthal M, Busse WR, Goldberg A, et al (eds). The Complete German Commission E
Monographs. Austin, TX:American Botanical Council 1998, pp. 169-170, 563-565.
Blumenthal M, Golberg A, Brinckmann. Herbal Medicine: Expanded Commission E
Monographs. Integrative Medicine Communications, Boston. 2000.
Bode JC, Schmidt V, Durr HK. Silymarin for the treatment of acute viral hepatitis? Report
of a controlled trial. Medizinische Klinik 1977;72:513-518.
Bone K. Silybum marianum. MediHerb 1996;2:22-23.
Bosisio E, Benelli C, Pirola O. Effect of the flavanolignans of Silybum marianum L on
lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes
Pharmacological Research 1992;25:147-154.
Cavallini L, Bindoli A, Siliprandi N. Comparative evaluation of antiperoxidative action of
silymarin and other flavonoids. Pharmacological Research Communications 1978;10:133-136.
Chasseaud LF. Adv Cancer Res 1979;29:175-274.
Clarke J, Snelling J, Ioannides C, Flatt PR, Barnett CR. Effect of vitamin C
supplementation on hepatic cytochrome P450 mixed-function oxidase activity in
streptozotocin-diabetic rats. Toxicol.Lett. 1996;89:249-56.
Das KK, Das SN, DasGupta S. The influence of ascorbic acid on nickel-induced hepatic
lipid peroxidation in rats. J Basic Clin.Physiol Pharmacol. 2001;12:187-95.
Davila J, Leuhern A, Acosta D. Protective effect of flavonoids on drug-induced
hepatotoxicity in vitro. Toxicology 1989;57:267-286.
De Flora S, Cesarone CF, Balansky RM et al. Chemopreventive properties and
mechanisms of N-acetylcysteine. The experimental background. J.Cell.Biochem. 1995;58
Suppl. 22:33-41.
De Rosa SC, Zaretsky MD, Dubs JG et al. N-acetylcysteine replenishes glutathione in
HIV infection. Eur.J.Clin.Invest. 2000;30:915-29.
Der Marderosian A, Liberti L. Natural Product Medicine: A scientific guide to foods,
drugs, cosmetics. Philadelpha, PA:George F Stickley Co., 1988.
Der Toxisch-Metabolisliche Leberschaden Hans. Lubeck:Verl-Kontor, 1981.
Desplaces A, Choppin J, Vogel G, et al. The effects of silymarin on experimental
phaloidine poisoning. Arzneimittelforshung/Drug Research 1975;25:89-96.
DiMario ER, Farni L, Okolicsanyi L, et al. The effects of silymarin on the liver function
parameters of patients with alcohol-induced liver diseases:a double-glind study, in: de
Ritis E, Csomos G, Braatz R, eds.
Dutton GJ. Glucuronidation of drugs and other compounds. Boca Raton, FL: CRC Press,1980.
Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on betaglucuronidase activity and glucarate content of certain vegetables and fruits. Biochem
Med Metab Biol 1990;43(2):83-92.
Fantozzi R, Brunelleschi S, Rubino A, et al. FLMP-activated neutrophils evoke histamine
release from mast cells. Agents and Actions 1986;18:155-156.
Feher J, Deak G, Muzes G, et al. Hepatoprotective activity of silymarin (Legalon®)
therapy in patients with chronic alcoholic liver disease. Orvosi Hetilap 1989;130:2723-
Feher J, Lang I, Nekam K, et al. In vivo effect of free radical scavenger hepatoprotective
agents on superoxide dismutase (SOD) activity in patients. Tokai Journal of Experimental
and Clinical Medicine 1990;15:129-134.
Ferenci P, Dragosics B, Dittroch H, et al. Randomized controlled trial of silymarin
treatment in patients with cirrhosis of the liver. Journal of Hepatology 1989;9:105-113.
Fintelmann V and Albert A. The therapeutic activity of Legalon in toxic hepatic disorders
demonstrated in a double-blind trial. Therapiewoche 1980;30:5589-5594.
Fox SI. Human Physiology. 4th ed. Dubuque, IA: Wm. C. Brown Publishers, 1993.
Grungreiff K, Albrecht M, Strenge-Hesse A. The value of drug therapy for liver disease in
general practice. Medizinische Welt 1995;46:222-227.
Guengerich FP. Cancer Res 1988;48:2946-54.
Hahn G, Lehmann H, Kurten M, et al. On the pharmacology and toxicology of
silymarin,an antihepatotoxic active principle from Silybum marianum (L.) Gaerti.
Arzneimittelforschung/Drug Research 1968;18:608-704.
Hanaue H, Kanno K, Mukai M et al. Estimation of the functional reserve of the human
liver by urinary D-glucaric acid excretion after vitamin C administration. Tokai.J Exp
Clin Med 1993;18:1-4.
Hardman JG, Limbird LE, eds. Goodman and Gilman’s The Pharmacological Basis of
Therapeutics. 9th ed. New York: McGraw Hill, 1996.
Hathcock JN. Vitamin and Mineral Safety. Vitamin C. Council for Responsible Nutrition:
Washington, DC, 1997, pp. 33-38.
Heerdt AS, et al. Calcium D-glucarate as a chemopreventive agent in breast cancer. Isr J
Med Sci 1995;31:101-5.
Hikino H, Kiso Y. Natural products for liver disease. In:Wagner H, Hikino H, Fansworth
NR (eds). Economic and Medicinal Plant Research, 2. London, England:Academic Press, 1988.
Hobbs C. Milk Thistle:The Liver Herb. 2nd edition. Capitola, CA:Botanica Press, 1984.
Kelly GS. Clinical applications of N-acetylcysteine. Altern.Med.Rev. 1998;3:114-27.
Kurz-Dimitrova D. Hepatoprotective treatment for neuropsychiatric patients receiving
long-term therapy with psychotropic drugs. Zeitschrift fur Praklinische Geriatri
Locher R, Suter PM, Weyhenmeyer R, Vetter W. Inhibitory action of silibinin on low
density lipoprotein oxidation. Arzneimittelforschung/Drug Research 1998;48(3):236-239.
McPartland, J.M. 1996. Viral hepatitis treated with Phyllanthus amarus and milk thistle
(Silybum marianum): a case report. Complementary Medicine International 1996;3(2):40–
Milk Thistle–Silybum marianum. In: Foster S, ed. Herbs for Your Health. Loveland, CO:
Interweave Press 1996:66-7.
Morazzoni P and Bombardelli E. Silybum marianum (Carduus marianus). Fitoterapia
Mourelle M, Favari L. Silymarin improves metabolism and disposition of aspirin in
cirrhotic rats. Life Sciences 1988;43:201-207.
Muzes G, Deak G, Lang I, et al. Effect of the bioflavonoid silymarin on the in vitro
activity and expression of superoxide dismutase (SOD) enzyme. Acta Physiologica
Hungarica 1991;78:3-9.
Nakano H, Boudjema K, Alexandre E et al. Protective effects of N-acetylcysteine on
hypothermic ischemia- reperfusion injury of rat liver. Hepatology 1995;22:539-45.
National Academy of Sciences. Chapter 5—Vitamin C. In: Dietary Reference Intakes for
Vitamin C, Vitamin E, Selenium, and Carotenoids. A Report of the Panel on Dietary
Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of
Nutrients and Interpretation and Uses of Dietary Reference Intakes, and the Standing
Committee on the Scientific Evaluation of Dietary Reference Intakes. Food and Nutrition
Board, Institute of Medicine. National Academy Press:Washington, DC, 2000, pp. 95- 185.
No Authors Listed. Calcium-D-glucarate. Altern Med Rev. 2002;7(4):336-9.
Oredipe OA, et al. Dietary D-glucarate mediated inhibition of initiation of
diethylnitrosamine-induced hepatocarcinogenesis. Toxicity 1992;74(2-3):209-22.
Pendyala L, Creaven PJ. Pharmacokinetic and pharmacodynamic studies of Nacetylcysteine, a potential chemopreventive agent during a phase I trial. Cancer
Epidemiol.Biomarkers Prev. 1995;4:245-51.
Salmi, H.A. and S. Sarna. 1982. Effect of silymarin on chemical, functional, and
morphological alterations of the liver. A double-blind controlled study. Scand J
Gastroenterol 17(4):517–521.
Shear N, Malkiewica I, Klein D, et al. Acetominophen-induced toxicity to human
epidermoid cell line A431 and hepatoblastoma cell line Hep G2, in vitro, is diminished by
silymarin. Skin Pharmacology 1995;8:279-291.
Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th
ed. Baltimore: Lippincott Williams & Wilkins, 1999.
Slaga T, Quilici-Timmcke J. Calcium D-Glucarate, A Nutrient Against Cancer. Keats
Publishing, Los Angeles, CA. 1999.
Szilard S, Szentgyorgi D, Demeter D. Protective effect of Legalon® in workers exposed
to organic solvents. Acta Medica Hungarica 1988;45:249-256.
Tittel G and Wagner H. High performance liquid chromatographic seperation of
silymarins and their determination in a raw extract of Silybum marianum Gaertn. Journal
of Chromatography 1977;135:499-501.
Valenzuela A and Guerra R. Differential effect of silybin on the Fe2+-ADP and t-butyl
hydroperoxide-induced microsomal lipid peroxidation. Experientia 1986;42:139-141.
Valenzuela A, Aspillaga M, Vial S, et al. Selectivity of silymarin on the increase of the
glutathione content in different tissues of the rat. Planta Medica 1989;55:420-442.
Valenzuela A, Guerra R, Videla I. Antioxidant properties of the flavnoids silybin and (+)-
cyanidanol-3:comparison with butylated hydroxyanisole and butylated hydroxytoluene.
Planta Medica 1986;49:438-440.
Valenzuela A, Lagos C, Schmidt K, et al. Silymarin protection against hepatic lipid
peroxidation induced by acute ethanol intoxication in the rat. Biochemical Pharmacology
Wagner H, Diesel P, Seitz M. The chemistry and analysis of silymarin from Silybum
marianum Gaeertn. Arzneimittelforschung/Drug Research 1974;24:466-471.
Walaszek Z, Flores E, Adams AK. Effect of dietary glucarate on estrogen receptors and
growth of 7-12-dimethylbenz[a]anthracene-induced rat mammary carcinomas. Breast
Cancer Res 1988;12:128.
Walaszek Z, Hanausek-Walaszek M, Minton JP, Webb TE. Dietary glucarate as antipromoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis.
Carcinogenesis 1986;7:1463-6.
Walaszek Z, Hanausek-Walaszek M, Webb TE. Repression by sustained-release betaglucuronidase inhibitors of chemical carcinogen-mediated induction of a marker oncofetal
protein in rodents. J Toxicol Environ Health 1988;23:15-27.
Walaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of D-glucaric
acid salt and its potential use in cancer prevention. Canc Detect Prevent 1997;21(2):178- 90.
Walaszek Z. Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat
mammary gland. Cancer Lett 1990;49:51-7.
Walaszek Z. Potential use of D-glucaric acid derivatives in cancer prevention. Canc Let
Wattenberg LW. Inhibition of carcinogenesis by minor dietary constituents. Cancer
Research 1992;52:2085-91.
Werback M and Murray M. Botanical Influences on Illness: A Sourcebook of Clinical
Research. Tarzana, CA:Third Line Press, 1994

Categories Uncategorized

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this:
search previous next tag category expand menu location phone mail time cart zoom edit close