Combined inhibition

Combined inhibition of invasive behavior of metastatic breast cancer cells by Ganoderma lucidum and green

Acta Pharmacologica Sinica [Abstracts of the 15th World Congress of Pharmacology, July 2-7, 2006, Beijing, China] 2006 July; Supplement 1:1-489. (pg. 338). Reishi mushroom extract and green tea extract used by Thyagarajan et al. in their 2006 publication: ReishiMaxGLp, and Tegreen 97, [Pharmanex (Provo, UT)] Combined inhibition of invasive behavior of metastatic breast cancercells by Ganoderma lucidum and green tea.Daniel Sliva1,2,3 and Anita Thyagarajan1. 1Cancer Research Laboratory, Methodist Research Institute, 1800 NCapitol Ave, E504, Indianapolis, 2Department of Medicine, and 3 Indiana University Cancer Center, IndianaUniversity School of Medicine, Indianapolis, IN, USA.
ABSTRACT
The objective of the present study was to evaluate the combined effects of dietary supplements consisting of Ganoderma lucidum (GL) and green tea (GT) extracts on human breast cancer cells MDA-MB-231. The effect on growth was evaluated by the inhibition of cell proliferation (anchorage-dependent growth) and colony formation (anchorage-independent growth), whereas the effect on invasive behavior was evaluated by the inhibition of cell adhesion to vitronectin, cell migration and cell invasion through matrigel. GL as well as GT inhibited proliferation and colony formation of MDA-MB- 231 cells in a dose-dependent manner, and these effects were profoundly enhanced by the combination of GL/GT. In addition, the combination of GL/GT demonstrated synergism against invasive behavior of breast cancer cells. The inhibition of cell invasiveness (adhesion, migration invasion) is mediated through the urokinaseplasminogen activator (uPA), since GT, GL as well as GT/GL suppressed secretion of uPA. In summary, combination of G. lucidum and green tea extracts could be considered in the prevention/therapy
of breast cancer. Keywords: G. lucidum, tea, cancer. Acknowledgment: This work was supported by Pharmanex LLC. Copyright laws prohibit the distribution of copies of the full-length Thyagarajan 2006 article; however for your
convenience please find the study abstract below. The full-length version of this article is available free of charge at
the following internet link: http://www.spandidos-publications.com/ijmm/article.jsp?article_id=ijmm_18_4_657 When you have accessed the above webpage, please click “Download PDF” Journal reference: Thyagarajan A, Jiang J, Hopf A, Adamec J, Sliva D. Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion. International Journal of Molecular Medicine. 2006 Oct;18(4):657-64. Reishi extract used by Thyagarajan et al. in their 2006 publication: ReishiMaxGLp [Pharmanex (Provo, UT)]
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