Autumn 2021

“Reishi and Immunity Oct 10, 2011 : A Scientific Overview Presented by Michael N. Chang, Ph.D.Chief Scientific Advisor, Nu Skin Enterprises, Inc. This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.

The Human Immune System 1. Removes waste and harmful material, to ensure the normal function of the body. 2. Defends against pathogens – bacteria, fungi and virus. 3. Kills and removes dead cells that have been altered as a natural process of the cell rejuvenation function. ……is a complicated network of cells, antibodies and proteins that serves following three main functions: … is delicately balanced by a very sophisticated feedback regulation and control system

Immune Cells Recognize and Destroy: Invading Organisms and Damaged Cells Chemical message alerts immune system that an invader is present Immune cell “swallows” foreign invader

Cell Surface Antigen How does it work? • Pathogens, such as bacteria, fungus, virus, have carbohydrates protruding outside of its surface. • Cells that have been altered during the normal cell rejuvenation process also have carbohydrate antigens protruding.

Reishi Mushroom Reishi (Ganoderma lucidum) mushroom is a fungus occurring as a shelf-like form growing on trees and stumps in densely wooded mountainous areas with high moisture and low light. The spores of Reishi have tough outer shells that make it difficult to obtain the nutrients inside. The rarity of Reishi is partly attributed to the difficulty of germination.”

Powerpoint presentation here:

https://www.slideserve.com/Mercy/the-human-immune-system

Free Register Wholesale price. nuskin.com Sponzor ID Alexander Vasko SK5500064.

ReishiMax GLp is a standardized Reishi mushroom extract that incorporates cracked spores, a proprietary technology that releases Reishi’s active ingredients, providing unique immune system activity not found in other Reishi products. *

Yang J, Wu Z, Yao Y, Zhang Y, Zhao C, Dong Y, Tan NZ, Zhu JS. ReishiMax improves antioxidant capacity in an oxidative stress model and extends lifespan in a natural aging model. FASEB J. April 2012 (26): 373.2. http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/373.2

Wu Z, Zhang Y, Tan NZ, Zhao C, Zhu JS. ReishiMax extends the lifespan of mice: A preliminary report  FASEB J, 2011 25:Abstract #601.2. http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/601.2

Tan NZ1, Zhang Y1, Yang J1, Zhao C1, Zhu JS2,3. ReishiMax extends the lifespan in an aging model: A preliminary report. FASEB J. April 2010 (24): Abstract #738.5. http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/738.5

Thyagarajan-Sahu A, Lane B, Sliva D. ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK. BMC Complement Altern Med. 2011 Sep 19;11:74. http://www.biomedcentral.com/content/pdf/1472-6882-11-74.pdf

Thyagarajan A, Jedinak A, Nguyen H, Terry C, Baldridge LA, Jiang J, Sliva D. Nutr Cancer. 2010;62(5):630-40. http://www.ncbi.nlm.nih.gov/pubmed/20574924

Adamec J, Jannasch A, Dudhgaonkar S, Jedinak A, Sedlak M, Sliva D. Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: determination of a triterpenoid metabolic fingerprint for the in situ characterization of Ganoderma bioactive compounds. J Sep Sci. 2009 Dec;32(23-24):4052-8. http://www.ncbi.nlm.nih.gov/pubmed/19937965

Dudhgaonkar S, Thyagarajan A, Sliva D. Int Immunopharmacol. 2009 Oct;9(11):1272-80. http://www.ncbi.nlm.nih.gov/pubmed/19651243

Zhang Y, Zhang L, Tan NZ, Qi Y, Gao L, Zhu JS FASEB J. March 2008 22 (Meeting Abstract Supplement) 1136.2. http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/1136.2

Thyagarajan A, Zhu J, Sliva D. International Journal of Oncology. 2007 Apr;30(4):963-9. http://www.spandidos-publications.com/ijo/article.jsp?article_id=ijo_30_4_963

Chen W, Zhang Y, Tan NZ, Qi Y, Zhu JS. FASEB J. Meeting Abstracts, 2007, 21(6): Abstract# 852.3. http://www.fasebj.org/cgi/content/meeting_abstract/21/6/A1100-a

Sliva, D, and Thyagararjan, A., Acta Pharmacologica Sinica [Abstracts of the 15th World Congress of Pharmacology, July 2-7, 2006, Beijing, China] 2006 July; Supplement 1:1-489. (pg. 338). http://www.blackwell-synergy.com/doi/abs/10.1111/j.1745-7254.2006.00453.x

Thyagarajan A, Jiang J, Hopf A, Adamec J, Sliva D. International Journal of Molecular Medicine. 2006 Oct;18(4):657-64. http://www.spandidos-publications.com/ijmm/article.jsp?article_id=ijmm_18_4_657

Thyagarajan A, Jiang J, Stanley G, Sliva D.  FASEB J., 2006; 20(5):A1012, Abstract# 652.6. http://www.fasebj.org/cgi/content/meeting_abstract/20/5/A1012-c

Jiang J, Slivova V, Sliva D. International Journal of Oncology, 2006, 29(3), 695–703. http://www.spandidos-publications.com/ijo/article.jsp?article_id=ijo_29_3_695

Stanley G, Harvey K, Slivova V, Jiang J, Sliva D. Biochem Biophys Res Commun. 2005 Apr 29;330(1):46-52.  http://www.ncbi.nlm.nih.gov/pubmed/15781230

Jiang J, Slivova V, Harvey V, Valachovicova T, and Sliva D. Nutrition and Cancer, 2004, 49(2), 209–216.http://www.ncbi.nlm.nih.gov/pubmed/15489214?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Slivovas, V., Valachoviciva, T., Jiang, J., Sliva, D. Journal of Cancer Integrative Medicine, 2004; 2:1, pp. 25-30. http://pnpcsw.pnpco.com/cadmus/testvol.asp?journal=jcim&year=2004

Sliva, D., Sedlak, M., Slivova, V., Valachovicova, T., Lloyd, F., HO, NW. Journal of Alternative and Complementary Medicine, 2003; 9:4, pp. 491-497. http://www.ncbi.nlm.nih.gov/pubmed/14499024?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Lu QYa, Jin YSb, Zhang Qa, Zhang Zc, Heber Da, Go VLa, Li FPd, Rao JYb. Cancer Letters. 2004;216 (1):9-20. http://www.ncbi.nlm.nih.gov/pubmed/15500944?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Lin, W.C., Wu, Y.W., Xie, M.C., Zhu, J.S., FASEB J. 2004; 18(4): A999 (Abstract #650.7). http://www.px2.com.tw/poster/No6.ReishiMax%20liver%20poster%20EB04.pdf

Jiang, J., Slivova, V., Valachovicova, T., Harvey, K., Sliva, D. International Journal of Oncology, 2004, 24: 1093-1099. http://www.spandidos-publications.com/ijo/24/5/1093

Zhao, C., Zhang, Y., Yin, W., Zhang, D., Guo, F., Zhu, JS. FASEB J., 17: A1099, 2003, Abstract# 689.4. http://www.px2.com.tw/poster/No5.ReishiMax%20FASEB%20poster.pdf

Wang YY, Wong CH, et al. Bioorganic & Medicinal Chemistry 2002;10:1057-1062. http://www.ncbi.nlm.nih.gov/pubmed/11836115?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Ma J, Ye Q, Hua Y, Zhang D, Cooper R, Chang MN, Chang JY, Sun HH. New lanostanoids from the mushroom Ganoderma lucidum. Journal of Natural Product, 2002 Jan;65(1):72-5. http://pubs.acs.org/cgi-bin/abstract.cgi/jnprdf/2002/65/i01/abs/np010385e.html

Li C, Li Y, Sun HH. New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum. Nat Prod Res. 2006 Sep;20(11):985-91. http://www.ncbi.nlm.nih.gov/pubmed/17050181

Li C, Yin J, Guo F, Zhang D, Sun HH: Ganoderic acid Sz, a new lanostanoid from the mushroom Ganoderma lucidum. Nat Prod Res. 2005 July; 19(5), 461–465. http://www.ncbi.nlm.nih.gov/pubmed/15938193

Tan N-Z, Chiang B-L, Thyagarajan A, Sliva D, Zhao C-S, Zhang Y, Zhu J-S. Proceedings of The 2011 International Meeting on Ganoderma Research. Aug. 17, 2011 Beijing. pp 44-46. Link

Yang JY, Zhang Y, Zhao C-S, Tan N-Z, Zhu J-S. Anti-oxidation and lifespan-extension activities of ReishiMax in oxidative stress and aging models. Proceedings of The 2011 International Meeting on Ganoderma Research. Aug. 17, 2011 Beijing. pp 47-49. https://www.researchgate.net/publication/280581216_Anti-oxidation_and_lifespan-extension_activities_of_ReishiMax_in_oxidative_stress_and_aging_models

Tan NZ, Li CL, Thyagarajan A, Sliva D, Zhang Y, Gao L, Zhu J-S. Proceedings of 2008 Symposium of Chin Asso Med Mycol. Oct 7-9, 2008 Nanchang, Jiangxi. Chinese Association of Medicinal Mycology Publishing, pp 165-171. Link

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