Reishi extracts

Pre-Clinical Studies
“Ample amounts of data from animal and in vitro studies strongly support that Reishi extracts can enhance cellular immunity by influencing lymphocytes, natural killer (NK) cells, cytokines, macrophages, and histamine release from mast cells, thus resulting in improved health benefits.The data from numerous animal models and in vitro studies performed with various Reishi extracts is summarized below: An unpublished comparative study recently conducted bybthe Medical Institute at National Taiwan University found
that ReishiMax™ enhanced immune function in mice compared to placebo (Chiang 2002). After six weeks, ReishiMax™ increased serum immunoglobulins (IgG, IgM, IgA), increased proliferation of lymphocytes, and
increased secretion of cytokines (IL-2, IL-5, IL-6) In relation to serum IgG, ReishiMax™ was 25% more effective than placebo, and just as effective as the leading Reishi competitor in Taiwan (at 0.585 g/kg). In relation
to IL-2, ReishiMax™ was 405% more effective than placebo, and was also more effective than the leading Reishi competitor in Taiwan (at 0.585 g/kg).
Clinical Studies
In clinical studies, Reishi extracts have been shown to increase levels of T-cell counts, CD4/CD8 ratio, cytokine IL-2, complement C3 and immunoglobulin G, lower levels of T-suppressor cell counts, improve vigor
and appetite, and shorten recovery time (Kupin 1992, Yang 1996). An open-label, comparative study evaluated the health benefits of Reishi supplementation in 48 individuals. Compared to controls, immune cell proliferation was improved. No adverse effects were seen with Reishi administration (Kupin 1992). Another open-label, comparative clinical study evaluated the health benefits of Reishi supplementation in 37 subjects. After six weeks, the values for debility and weakness were lowered by 53.6%. Their lymphoid transformation rate increased, and levels of IL-2, complement C3, and immunoglobulin G were significantly higher after supplementation with Reishi (p<0.05) (Yang 1996).
Proprietary Processing
The combination of quality ingredients, qualified manufacturers, certified independent laboratory verification, and a continuous drive to supply leading edge products, ensure our distributors and consumers the
highest quality products available in the industry. The constituents in ReishiMax™ are standardized through
scientific and analytical methods to ensure that every capsule contains the specific level of constituents,
every time. The production, quality control, safety and efficacy studies for ReishiMax™ have been reviewed and approved by the Taiwan Department of Health (DOH) and Expert Committee (DOH 2002). A health food license was granted for ReishiMax™ by the Taiwan DOH in April 2002, one of only 23 licenses that have been issued for health foods by the DOH. ReishiMax™ is produced through solid wood log cultivation, which requires a 120–200 day cultivation period. This method is preferred to sawdust and liquid cultivation
because it yields both polysaccharides and triterpenes from the fruiting body. In addition, other cultivation
methods are prone to contamination and are difficult to control quality. Pharmanex has developed an exclusive multi-step extraction process that increases the yield and concentration of active ingredients. Most Reishi products only use one extraction process, which results in a product with lower concentrations of active ingredients, and often lacks the triterpene compounds. The first step of Pharmanex’s extraction process concentrates the triterpenes, while the second step concentrates the polysaccharides. The third and final step in Pharmanex extraction process utilizes an exclusive technology that detaches additional
polysaccharides from the cell walls. The resulting product, ReishiMax™, is standardized to 6% triterpenes and 13.5% polysaccharides, which is the highest level of actives currently available in a Reishi product. ReishiMax™ also incorporates a novel cracked spore technology, which releases additional active ingredients,
providing unique immune activity not found in other Reishi products.Reishi spores are minute brown eggshaped reproductive cells that are released by the mushroom at maturity. The spores are protected by an
extremely hard shell, which prevents the polysaccharides and triterpenes contained in the spore from being
absorbed. Pharmanex uses technology which mechanically ‘cracks’ the spores, making the active ingredients
bioavailable (see picture below). All ingredients are tested for purity, and where applicable, ingredients are certified pure by microbial testing, such as tests for Salmonella, E. coli, other coliforms, Staphylococcus aureus, total plate counts, yeasts, and molds. Our manufacturers go through a detailed selection and
certification process to assure their compliance with Good Manufacturing Practice (GMP) standards set by the Food and Drug Administration FDP ReishiMax™ is supplied in a 15-30 day supply of 60 capsules.”

(nuskin.com)

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